The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.

@article{You2009TheON,
  title={The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.},
  author={Bei You and Yuan-ying Jiang and Shaoping Chen and Guijun Yan and Jianxin Sun},
  journal={Circulation research},
  year={2009},
  volume={104 6},
  pages={742-9}
}
Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. Nur77 is highly expressed in vascular endothelial cells (ECs) and plays a role in the regulation of cell proliferation and angiogenesis; its role in vascular inflammation, however, remains unknown. Treatment of human umbilical vein ECs (HUVECs) with tumor necrosis factor (TNF)-alpha substantially increased the transcription and protein… CONTINUE READING
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