The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter.

@article{Freeman2004TheON,
  title={The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter.},
  author={Lita A. Freeman and Arion Kennedy and Justina Wu and Samantha Bark and Alan T Remaley and Silvia Santamarina-Fojo and Hollis B Brewer},
  journal={Journal of lipid research},
  year={2004},
  volume={45 7},
  pages={1197-206}
}
The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG5 and ABCG8 promoters. Mutating this LRH-1 binding site reduced promoter activity of the human ABCG5/ABCG8 intergenic region more than 7-fold in HepG2 and Caco2 cells… CONTINUE READING

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