The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.

@article{Mendiola2006TheON,
  title={The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.},
  author={Marta Mendiola and Jaime Carrillo and Eva S{\'a}nchez Garc{\'i}a and Enzo Lalli and T. Hernandez and Enrique de {\'A}lava and Franck Tirode and Olivier Delattre and Purificaci{\'o}n Garc{\'i}a-Miguel and Fernando L{\'o}pez-Barea and Angel Pesta{\~n}a and Javier Alonso},
  journal={International journal of cancer},
  year={2006},
  volume={118 6},
  pages={1381-9}
}
The Ewing family of tumors harbors chromosomal translocations that join the N-terminal region of the EWS gene with the C-terminal region of several transcription factors of the ETS family, mainly FLI1, resulting in chimeric transcription factors that play a pivotal role in the pathogenesis of Ewing tumors. To identify downstream targets of the EWS/FLI1 fusion protein, we established 293 cells expressing constitutively either the chimeric EWS/FLI1 or wild type FLI1 proteins and used cDNA arrays… CONTINUE READING

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