The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

@article{Lau2008TheON,
  title={The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.},
  author={Patrick Lau and Rebecca L. Fitzsimmons and Suryaprakash Raichur and Shu-Ching Wang and Adriane Lechtken and George E. O. Muscat},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 26},
  pages={
          18411-21
        }
}
Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid receptor-related orphan receptor alpha (RORalpha) expression. We observed decreases in serum (and liver) triglycerides and total and high density lipoprotein serum cholesterol in sg/sg mice. Moreover, the sg/sg mice were characterized by reduced adiposity (associated with decreased fat pad mass and adipocyte size). Candidate-based expression profiling demonstrated that the dyslipidemia in sg/sg mice is… CONTINUE READING

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