The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

@article{Lau2008TheON,
  title={The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.},
  author={P. Lau and R. Fitzsimmons and S. Raichur and S. Wang and A. Lechtken and G. Muscat},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 26},
  pages={
          18411-21
        }
}
Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid receptor-related orphan receptor alpha (RORalpha) expression. We observed decreases in serum (and liver) triglycerides and total and high density lipoprotein serum cholesterol in sg/sg mice. Moreover, the sg/sg mice were characterized by reduced adiposity (associated with decreased fat pad mass and adipocyte size). Candidate-based expression profiling demonstrated that the dyslipidemia in sg/sg mice is… Expand
146 Citations
Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.
  • 68
  • Highly Influenced
  • PDF
RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages
  • 14
  • PDF
Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control
  • 4
  • PDF
Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
  • 24
  • PDF
Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle
  • 44
  • PDF
The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis.
  • 14
  • Highly Influenced
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORα*
  • 127
  • PDF
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
  • 1,178
  • PDF
The Liver X Receptor (LXR) and Hepatic Lipogenesis
  • J. Cha, J. Repa
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 2007
  • 352
  • PDF
Transcriptional Regulation of Apolipoprotein A-I Gene Expression by the Nuclear Receptor RORα*
  • 128
  • PDF
...
1
2
3
4
5
...