The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.

Abstract

Cytochrome P-450 3A4 (CYP3A4), the predominant cytochrome P-450 expressed in adult human liver, is subject to transcriptional induction by a variety of structurally unrelated xenobiotics, including the antibiotic rifampicin. The molecular mechanisms underlying this phenomenon are poorly understood. We transfected a human liver-derived cell line (HepG2) with… (More)

Topics

9 Figures and Tables

Cite this paper

@article{Goodwin1999TheOH, title={The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.}, author={Bryan J Goodwin and Ecushla Hodgson and Christopher Liddle}, journal={Molecular pharmacology}, year={1999}, volume={56 6}, pages={1329-39} }