The orphan disease networks.

@article{Zhang2011TheOD,
  title={The orphan disease networks.},
  author={Minlu Zhang and Cheng Zhu and Alexis Jacomy and Long Jason Lu and Anil G. Jegga},
  journal={American journal of human genetics},
  year={2011},
  volume={88 6},
  pages={755-766}
}
The low prevalence rate of orphan diseases (OD) requires special combined efforts to improve diagnosis, prevention, and discovery of novel therapeutic strategies. To identify and investigate relationships based on shared genes or shared functional features, we have conducted a bioinformatic-based global analysis of all orphan diseases with known disease-causing mutant genes. Starting with a bipartite network of known OD and OD-causing mutant genes and using the human protein interactome, we… CONTINUE READING

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