The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.

@article{Tabata2007TheOG,
  title={The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.},
  author={Ken-ichi Tabata and Kiyoshi Baba and Akira Shiraishi and Masahiro Ito and Norihisa Fujita},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={363 3},
  pages={861-6}
}
In CHO cells stably expressing the GPR87 fused with a G16alpha protein, lysophosphatidic acid (LPA) evoked an intracellular Ca(2+) increase in a high affinity manner. The Ca(2+) increase was reversibly blocked by the LPA receptor antagonists and inhibited by pretreatment of the cells with GPR87-specific siRNAs. GPR87 was shown to be closer to the P2Y and P2Y-related receptors than LPA receptors by ClustalW analyses. However, none of nucleotides and their derivatives activated GPR87. The human… CONTINUE READING

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