The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.

@article{Thathiah2009TheOG,
  title={The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.},
  author={Amantha Thathiah and Kurt Spittaels and Marcel Hoffmann and Mik Staes and Adrian M Cohen and Katri{\'e}n Horr{\'e} and Mieke Vanbrabant and Frea Coun and Veerle Baekelandt and Andr{\'e} Delacourte and David F. Fischer and Dirk Pollet and Bart De Strooper and Pascal Merchiers},
  journal={Science},
  year={2009},
  volume={323 5916},
  pages={946-51}
}
Deposition of the amyloid-beta peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G protein-coupled receptor 3 (GPR3), a constitutively active orphan G protein-coupled receptor, as a modulator of amyloid-beta production. Overexpression of GPR3 stimulated amyloid-beta production, whereas genetic ablation of GPR3 prevented accumulation of the amyloid-beta peptide in vitro and in an Alzheimer's disease mouse model. GPR3 expression led… CONTINUE READING

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