The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine.

@article{Plissier2002TheOC,
  title={The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine.},
  author={Teresa P{\'e}lissier and Jacques Pajot and Radhouane Dallel},
  journal={Pain},
  year={2002},
  volume={96 1-2},
  pages={81-7}
}
The aim of this study was to develop a rat model of capsaicin-induced pain in the orofacial region. We examined the effects of subcutaneous injection of different doses of capsaicin (0.25, 0.4, 0.8, 1.5, 2.5, 25, 50, 100, 500 microg) on the face-grooming response. Injection of capsaicin into the vibrissa pad produced an immediate grooming of the injected area with ipsilateral fore- or hindpaw. A positive relationship between the amplitude of the grooming response and the capsaicin dose was… CONTINUE READING