The origins of the neutral theory of molecular evolution

@article{Dietrich1994TheOO,
  title={The origins of the neutral theory of molecular evolution},
  author={Michael R. Dietrich},
  journal={Journal of the History of Biology},
  year={1994},
  volume={27},
  pages={21-59}
}
  • M. Dietrich
  • Published 1994
  • Medicine
  • Journal of the History of Biology
Molecular biology has had a profound impact on the nature of the biological sciences in the twentieth century. Molecular techniques are found now in virtually every area of biology. To reduce the impact of molecular biology to the dissemination of its technologies, however, is to sell it short: it has also dramatically altered researchers' attitudes toward the question which problems or problem areas are of fundamental importance. This shift in attitude is nowhere more evident than in hybrid… Expand
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References

SHOWING 1-3 OF 3 REFERENCES
On some principles governing molecular evolution.
  • M. Kimura, T. Ohta
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1974
TLDR
Five Pillars of Evolution were culled from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions. Expand
The molecular clock may be an episodic clock.
  • J. Gillespie
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
It is argued that the apparent constancy of the rate of molecular evolution may be an artifact due to the very slow rate of evolution of individual amino acids, and that molecular evolution is episodic, with short bursts of rapid evolution followed by long periods of slow evolution. Expand
The causes of molecular evolution
Protein evolution DNA evolution The molecular clock Selection in a fluctuating environment Strong-selection, weak-mutation approximations Neutral Allele theories Selection theories.