The origins of the great pandemic

@article{Worobey2019TheOO,
  title={The origins of the great pandemic},
  author={Michael Worobey and Jim Cox and Douglas Gill},
  journal={Evolution, Medicine, and Public Health},
  year={2019},
  volume={2019},
  pages={18 - 25}
}
Abstract The timing and location of the first cases of the 1918 influenza pandemic are still controversial, a century after the pandemic became widely recognized. Here, we critically review competing hypotheses on the timing and geographical origin of this important outbreak and provide new historical insights into debates within military circles as to the nature of putative pre-1918 influenza activity. We also synthesize current knowledge about why the 1918 pandemic was so intense in young… 

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References

SHOWING 1-10 OF 28 REFERENCES

1918 Influenza: the Mother of All Pandemics

TLDR
New information about the 1918 virus is emerging, for example, sequencing of the entire genome from archival autopsy tissues, but, the viral genome alone is unlikely to provide answers to some critical questions.

Paths of Infection: The First World War and the Origins of the 1918 Influenza Pandemic

The origin site for the 1918 influenza pandemic which killed more than 50 million people worldwide has been hotly debated. While the mid-western United States, France, and China have all been

Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City.

TLDR
Using routinely collected monthly age-stratified mortality data, it is shown that an unmistakable shift in the age distribution of epidemic deaths occurred during the 1917/1918 influenza season in New York City.

Phylogenetic evidence for a mild H1 pandemic in the early 1900s

  • S. Riley
  • Medicine
    Proceedings of the National Academy of Sciences
  • 2014
TLDR
A new theory is presented—backed up by robust phylogenetic evidence—of a previously overlooked mild H1 influenza pandemic in the very early 1900s, and it is suggested that prior circulation of a previously unreported H1N8 strain for 10 y can explain both the number and age distribution of severe infections during the 1918 pandemic.

Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus

TLDR
The phylogenetic results suggest that the high mortality in 1918 among adults aged ∼20 to ∼40 y may have been due primarily to their childhood exposure to a doubly heterosubtypic putative H3N8 virus, which the authors estimate circulated from ∼1889–1900.

Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus

TLDR
Reverse genetics was used to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence, and confirmed that the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemicirus.

A synchronized global sweep of the internal genes of modern avian influenza virus

TLDR
It is shown that explicitly allowing IAV host lineages to have independent rates of molecular evolution is necessary for reliable phylogenetic inference of IAV and that methods that do not do so, including ‘relaxed’ molecular clock models, can be positively misleading.

Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak

TLDR
Clinical, pathological, bacteriological, and virological findings in 68 fatal American influenza/pneumonia military patients dying between May and October of 1918, a period that includes ∼4 mo before the 1918 pandemic was recognized, and 2 mo during which it appeared and peaked, have important implications for understanding the origins and evolution of pandemic influenza viruses.

Did the 1918–19 Influenza Pandemic Originate in China?

TLDR
It is conceivable that Chinese workers en route to France would have carried the virus with them, leading to the pandemic, and the most plausible explanation is that the 1918–19 influenza virus had originated in China, so that many Chinese had prior exposure and hence some immunity.