The origins of RNA catalysis in ribozymes.

  title={The origins of RNA catalysis in ribozymes.},
  author={David M. J. Lilley},
  journal={Trends in biochemical sciences},
  volume={28 9},
The discovery of RNA catalysis provided a paradigm shift in biology, insight into the evolution of life on the planet and a challenge to understand its mechanistic origins. RNA has limited catalytic resources that must be used to maximal effect. Consequently, RNA catalysis tends to be multifactorial, with several processes contributing to an overall significant enhancement of reaction rate. These include general acid-base catalysis, electrostatic effects, and substrate orientation and proximity… CONTINUE READING