The origins and implications of intratumor heterogeneity.

  title={The origins and implications of intratumor heterogeneity.},
  author={Franziska Michor and Korn{\'e}lia Poly{\'a}k},
  journal={Cancer prevention research},
  volume={3 11},
Human tumors often display startling intratumor heterogeneity in various features including histology, gene expression, genotype, and metastatic and proliferative potential. This phenotypic and genetic heterogeneity plays an important role in neoplasia, cancer progression, and therapeutic resistance. In this issue of the journal (beginning on page 1388), Merlo et al. report their use of molecular data from 239 patients with Barrett's esophagus to evaluate the propensity of major diversity… CONTINUE READING

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