The origin of urinary angiotensins in humans.

  title={The origin of urinary angiotensins in humans.},
  author={Pieter F Vos and Peter C. A. M. den Boer and Branko Braam and Hein A. Koomans},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={5 2},
To examine whether urinary angiotensin (ANG) I and II excretion responds to changes in plasma ANG I and ANG II, ANG I or ANG II was infused in seven healthy subjects pretreated with a 340-mmol sodium diet and 20 mg of enalapril twice daily. Infusion rates were 4, 8, 16, and 32 pmol/kg per minute for ANG I and 1, 4, and 8 pmol/kg per minute for ANG II. Baseline ANG I and ANG II excretions averaged 10 and 20 fmol/min, respectively, which is approximately 0.3 and 5% of the filtered loads. Despite… CONTINUE READING

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