The origin of two components in contraction of guinea pig papillary muscle in the presence of noradrenaline.

@article{Bogdanov1979TheOO,
  title={The origin of two components in contraction of guinea pig papillary muscle in the presence of noradrenaline.},
  author={K Y Bogdanov and Sergey I. Zakharov and Leonid V. Rosenshtraukh},
  journal={Canadian journal of physiology and pharmacology},
  year={1979},
  volume={57 8},
  pages={866-72}
}
In experiments on isolated guinea pig papillary muscles the effects of verapamil (5 mg/L) and caffeine (1 g/L) on the two-component contraction were investigated. The muscles were continuously superfused with normal Tyrode's solution containing 2 mg of noradrenaline/L at 20--22 degrees C. The first derivative of contractile response and transmembrane action potential were simultaneously recorded. Verapamil suppressed the amplitude of the second component and had no influence on the first… CONTINUE READING

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