The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

@article{Beatus2001TheOO,
  title={The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity},
  author={Paul Beatus and Johan Lundkvist and Camilla {\"O}berg and Kia Pedersen and Urban Lendahl},
  journal={Mechanisms of Development},
  year={2001},
  volume={104},
  pages={3-20}
}
Notch signal transduction is mediated by proteolysis of the receptor and translocation of the intracellular domain (IC) into the nucleus, where it functions as a regulator of HES gene expression after binding to the DNA-binding protein RBP-J kappa. The mammalian Notch receptors are structurally very similar, but have distinct functions. Most notably, Notch 1 IC is a potent activator of the HES promoter, while Notch 3 IC is a much weaker activator and can repress Notch 1 IC-mediated HES… CONTINUE READING