The origin of spontaneous activity in developing networks of the vertebrate nervous system

  title={The origin of spontaneous activity in developing networks of the vertebrate nervous system},
  author={Michael J. O'Donovan},
  journal={Current Opinion in Neurobiology},
Development of Spontaneous Activity in the Avian Hindbrain
This work reviews spontaneous activity in the chick hindbrain by focusing on this large-scale synchronized activity that recruits a large population of neurons and propagates like a wave over a wide region of the central nervous system.
Spontaneous Network Activity and Synaptic Development
  • D. Kerschensteiner
  • Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2014
Common mechanisms and patterns of spontaneous activity in emerging neural networks are reviewed and recent insights into their contribution to synaptic development are discussed.
Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.
The spontaneous activity of the developing visual system between mammalian and Drosophila is compared and it is suggested that Drosophile is an emerging model for mechanistic and functional studies of correlated spontaneous activity.
Synaptic model for spontaneous activity in developing networks
Modeling developmental patterns of spontaneous activity
Modeling Spontaneous Episodic Activity in Developing Neuronal Networks
This model only represents the averaged activity and excitability in the network, assumed purely excitatory, and allowed a qualitative understanding of the network dynamics, which leads to prediction/comprehension of experimental observations.
Modeling of Spontaneous Activity in Developing Spinal Cord Using Activity-Dependent Depression in an Excitatory Network
An idealized, qualitative model of a homogeneous, excitatory recurrent network that could account for the multiple time-scale spontaneous activity in the embryonic chick spinal cord is developed and it is shown that cycling can arise from the interplay betweenexcitatory connectivity and fast synaptic depression.
Contribution of GABAergic Interneurons to the Development of Spontaneous Activity Patterns in Cultured Neocortical Networks
It is suggested that the richly interconnected large GABAergic neurons contribute to desynchronize and temporally differentiate the spontaneous activity of cultured cortical networks.
Theoretical models of spontaneous activity generation and propagation in the developing retina.
Several computational models used to help evaluate the mechanisms that might be responsible for the generation of retinal waves are reviewed, including gap junctions, neurotransmitters and second messenger systems.


Mechanisms of spontaneous activity in developing spinal networks.
Developing networks of the chick spinal cord become spontaneously active early in development and remain so until hatching. Experiments using an isolated preparation of the spinal cord have begun to
Population behavior and self-organization in the genesis of spontaneous rhythmic activity by developing spinal networks.
During development spinal networks generate recurring episodes of rhythmic bursting that can be recorded from motoneurons and interneurons, which are formulated into a qualitative model in which population behavior and self-organization are responsible for the spontaneous activity generated by developing spinal networks.
Retrograde signaling and the development of transmitter release properties in the invertebrate nervous system.
In organisms ranging from cats to crickets, evidence suggests that retrograde signaling is essential for matching these presynaptic release properties to individual postsynaptic partners.
Spontaneous impulse activity of rat retinal ganglion cells in prenatal life.
Recordings in vivo from the retinas of rat fetuses between embryonic day 17 and 21 found action potentials in spontaneously active ganglion cells at all the ages studied.
Presynaptic modulation of CA3 network activity
It is shown that population-burst duration is limited by depletion of the releasable glutamate pool at these recurrent synapses, which regulates the probability and duration of synchronous discharges of the CA3 network.
Coordinate activity in retinal and cortical development
  • L. C. Katz
  • Biology
    Current Opinion in Neurobiology
  • 1993