The origin of ovarian cancers--hypotheses and controversies.

  title={The origin of ovarian cancers--hypotheses and controversies.},
  author={Nelly Auersperg},
  journal={Frontiers in bioscience},
Ovarian cancer is the prime cause of death from gynecological malignancies in the Western world. In spite of its importance, it is poorly understood and its prognosis remains poor. The most common and lethal of all ovarian cancer subtypes are the high grade serous ovarian carcinomas (HGSOCs). A major problem in their clinical management is the current uncertainty about their cell type of origin, which limits means of early detection and prevention. It has not been resolved whether all HGSOCs… CONTINUE READING
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