The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.

Abstract

Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synaptic transmembrane current, other sources--including Na(+) and Ca(2+) spikes, ionic fluxes through voltage- and ligand-gated channels, and intrinsic membrane oscillations--can substantially shape the extracellular field. High-density recordings of field activity in animals and subdural grid recordings in humans, combined with recently developed data processing tools and computational modelling, can provide insight into the cooperative behaviour of neurons, their average synaptic input and their spiking output, and can increase our understanding of how these processes contribute to the extracellular signal.

DOI: 10.1038/nrn3241

Extracted Key Phrases

1 Figure or Table

Showing 1-10 of 356 extracted citations
0100200300201220132014201520162017
Citations per Year

984 Citations

Semantic Scholar estimates that this publication has received between 784 and 1,226 citations based on the available data.

See our FAQ for additional information.