The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

  title={The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes},
  author={G. Buzs{\'a}ki and Costas A. Anastassiou and C. Koch},
  journal={Nature Reviews Neuroscience},
  • G. Buzsáki, Costas A. Anastassiou, C. Koch
  • Published 2012
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synaptic transmembrane current, other sources — including Na+ and Ca2+ spikes, ionic fluxes through voltage- and ligand-gated channels, and intrinsic membrane oscillations — can substantially shape the extracellular field. High-density recordings of field activity in animals and subdural grid recordings in humans… CONTINUE READING
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