The origin of extracellular DNA during the clearance of dead and dying cells

@article{Pisetsky2007TheOO,
  title={The origin of extracellular DNA during the clearance of dead and dying cells},
  author={David S Pisetsky and Anna-Marie Fairhurst},
  journal={Autoimmunity},
  year={2007},
  volume={40},
  pages={281 - 284}
}
DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be mined by genomic techniques. Because of the association of extracellular DNA with clinical conditions marked by cell death, dead and dying cells have been considered the origin of… 
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References

SHOWING 1-10 OF 22 REFERENCES
The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells
TLDR
Results indicate that macrophages play an important role in the generation of extracellular DNA from dead and dying cells, with the effect dependent on how the cell died.
Release of DNA from Dead and Dying Lymphocyte and Monocyte Cell Lines In Vitro
TLDR
It is suggested that extracellular release of DNA is a consequence of apoptosis and may account for some of the DNA in the blood.
Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells.
TLDR
It is suggested that the generation of blood nucleosomes depends on macrophages, with apoptosis a concomitant of a high burden of dead and dying cells.
The Generation of Extracellular DNA in SLE: the Role of Death and Sex
TLDR
The origin of extracellular DNA circulating in the blood in SLE is clarified and steps in this process that can be interdicted by novel therapy are suggested.
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences.
TLDR
The task is to understand and explain these diametrically opposed reactions to stimulation of the same receptors, which when microbial organisms or their products are engulfed via these receptors, inflammation results, and in many cases, acquired immunity is stimulated.
Apoptosis and systemic lupus erythematosus.
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
TLDR
It is reported that Hmgb1-/- necrotic cells have a greatly reduced ability to promote inflammation, which proves that the release of HMGB1 can signal the demise of a cell to its neighbours, and cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma.
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