The origin of bovine spongiform encephalopathy: the human prion disease hypothesis

@article{Colchester2005TheOO,
  title={The origin of bovine spongiform encephalopathy: the human prion disease hypothesis},
  author={A. Colchester and N. Colchester},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={856-861}
}
The cause of the original case or cases of bovine spongiform encephalopathy (BSE) remains an enigma. Sheep scrapie or a previously undetected sporadic bovine transmissible spongiform encephalopathy (TSE) have long been considered as candidates, but no convincing evidence to support these proposals has come to light. We present a new theory, with three related hypotheses: (1) that BSE was acquired from a human TSE (prion disease); (2) that the route of infection was oral, through animal feed… Expand
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