The origin of a novel gene through overprinting in Escherichia coli

  title={The origin of a novel gene through overprinting in Escherichia coli},
  author={L. Delaye and Alexander DeLuna and Antonio Lazcano and Arturo Becerra},
  booktitle={BMC Evolutionary Biology},
Overlapped genes originate by a) loss of a stop codon among contiguous genes coded in different frames; b) shift to an upstream initiation codon of one of the contiguous genes; or c) by overprinting, whereby a novel open reading frame originates through point mutation inside an existing gene. Although overlapped genes are common in viruses, it is not clear whether overprinting has led to new genes in prokaryotes. Here we report the origin of a new gene through overprinting in Escherichia coli… CONTINUE READING

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