The origin and evolution of synapses

  title={The origin and evolution of synapses},
  author={Tom{\'a}s J. Ryan and Seth G. N. Grant},
  journal={Nature Reviews Neuroscience},
  • T. Ryan, S. Grant
  • Published 1 October 2009
  • Biology
  • Nature Reviews Neuroscience
Understanding the evolutionary origins of behaviour is a central aim in the study of biology and may lead to insights into human disorders. Synaptic transmission is observed in a wide range of invertebrate and vertebrate organisms and underlies their behaviour. Proteomic studies of the molecular components of the highly complex mammalian postsynaptic machinery point to an ancestral molecular machinery in unicellular organisms — the protosynapse — that existed before the evolution of metazoans… 

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