The origin and development of nonlymphoid tissue CD103+ DCs

  title={The origin and development of nonlymphoid tissue CD103+ DCs},
  author={Florent Ginhoux and Kang Liu and Julie Helft and Milena Bogunovic and Melanie Greter and Daigo Hashimoto and Jeremy C. Price and Na Yin and Jonathan Bromberg and Sergio A Lira and E Richard Stanley and Michel C. Nussenzweig and Miriam Merad},
  booktitle={The Journal of experimental medicine},
CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from… CONTINUE READING
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