The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids

@article{Gyi1998TheOA,
  title={The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids},
  author={Jeffrey I. Gyi and Andrew N. Lane and Graeme L. Conn and Tom Brown},
  journal={Nucleic acids research},
  year={1998},
  volume={26 13},
  pages={3104-10}
}
The stereochemical and dynamic properties of the C2' hydroxyl group in several DNA.RNA hybrids have been measured by NMR and compared with the homologous RNA duplex. The C2'-OH NMR signals of the RNA strands were identified, and numerous specific assignments were made. The rate constants for exchange of the hydroxyl protons with water were determined at 5 degrees C, and were found to depend on both the position within a particular sequence and the nature of the duplex. On average, the exchange… CONTINUE READING
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