The organotypic entorhinal-hippocampal complex slice culture of adolescent rats. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders.

@article{Diekmann1994TheOE,
  title={The organotypic entorhinal-hippocampal complex slice culture of adolescent rats. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders.},
  author={Silvia Diekmann and Robert Nitsch and Thomas Georg Ohm},
  journal={Journal of neural transmission. Supplementum},
  year={1994},
  volume={44},
  pages={61-71}
}
The entorhinal-hippocampal system is severely altered in many neurodegenerative disorders with mnemonic malfunction, e.g. Alzheimer's, Parkinson's and Huntington's disease. The present approach characterizes an organotypic complex slice culture comprising both the entorhinal cortex and the hippocampal formation in order to establish a tool for experimental studies of the entorhinal-hippocampal interaction and its presumed neurodegenerative alterations in vitro. Slices were obtained from rats at… CONTINUE READING

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