The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells

@article{Snapp2004TheOO,
  title={The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells},
  author={Erik Lee Snapp and Gretchen A. Reinhart and Brigitte Bogert and Jennifer Lippincott-Schwartz and Ramanujan S Hegde},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={997 - 1007}
}
Protein translocons of the mammalian endoplasmic reticulum are composed of numerous functional components whose organization during different stages of the transport cycle in vivo remains poorly understood. We have developed generally applicable methods based on fluorescence resonance energy transfer (FRET) to probe the relative proximities of endogenously expressed translocon components in cells. Examination of substrate-engaged translocons revealed oligomeric assemblies of the Sec61 complex… CONTINUE READING

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