The organization and regulation of the macrophage actin skeleton.

  title={The organization and regulation of the macrophage actin skeleton.},
  author={John H. Hartwig and Helen L. Yin},
  journal={Cell motility and the cytoskeleton},
  volume={10 1-2},
To move, leukocytes extend portions of their cortical cytoplasm as pseudopods. These pseudopods are filled with a three-dimensional actin filament skeleton, the reversible assembly of which in response to receptor stimulation is thought to play a major role in providing the mechanical force for these protrusive movements. The organization of this actin skeleton occurs at different levels within the cell, and a number of macrophage proteins have been isolated and shown to affect the architecture… CONTINUE READING


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