The oral retention and antiplaque efficacy of triclosan in human volunteers.

@article{Gilbert1987TheOR,
  title={The oral retention and antiplaque efficacy of triclosan in human volunteers.},
  author={Richard J. Gilbert and Phillip E. Williams},
  journal={British journal of clinical pharmacology},
  year={1987},
  volume={23 5},
  pages={579-83}
}
An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 +/- 1.4% of the triclosan was retained. The mean concentration (+/- s.d.) achieved in saliva 5 min after toothpaste use was 8.16 +/- 2.50 micrograms g-1. The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively… CONTINUE READING