The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation

@article{RomeroSandoval2004TheOA,
  title={The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation},
  author={E Alfonso Romero-Sandoval and Matilde Alique and Victoria Moreno-Manzano and Carlos Oliver Valderrama Molina and Francisco J Lucio and Juan Fernando Herrero},
  journal={Inflammation Research},
  year={2004},
  volume={53},
  pages={297-303}
}
Objective and design:To study the involvement of all-trans retinoic acid (ATRA) in the development and maintenance of inflammatory pain. Subjects:Adult male Wistar rats and murine neuro2a and human SH-SY5Y neuroblastoma cells. Treatment:Soft-tissue inflammation was induced by the intraplantar administration of 100 μl of carrageenan λ. The oral treatment with either ATRA or vehicle lasted for seven days and consisted in a dose of 15 mg/kg the first two days and a dose of 10 mg/kg the following… CONTINUE READING
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