The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease.

@article{Darsley2012TheOL,
  title={The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease.},
  author={Michael J Darsley and Subhra Chakraborty and Barbara Denearing and David A Sack and Andrea E Feller and Charlotte Buchwaldt and August Louis Bourgeois and Richard I. Walker and Clayton D Harro},
  journal={Clinical and vaccine immunology : CVI},
  year={2012},
  volume={19 12},
  pages={1921-31}
}
An oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, was demonstrated to generate strong immune responses to colonization factor and toxin antigens of enterotoxigenic Escherichia coli (ETEC) in human volunteers. The vaccine was safe and well tolerated at doses of up to 10(11) CFU, administered in each of two doses given 21 days apart. These observations have now been extended in a phase 2b study with a total of 70 subjects. Fifty-six of these subjects were challenged 28… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Vaccines against enterotoxigenic Escherichia coli infections. II. Live oral vaccines and subunit (purified fimbriae and toxin

C Tacket, M. Levine
subunit) vaccines, • 1997
View 5 Excerpts
Highly Influenced

Fimbriae (pili) adhesins as vaccines, p 143–145

M Levine, J Morris, G Losonsky, E Boedeker, B. Lowe
1986
View 5 Excerpts
Highly Influenced

A systematic review of experimental infections with enterotoxigenic Escherichia coli (ETEC)

CK Porter
Vaccine • 2011
View 2 Excerpts

A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enteroxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC

R McKenzie
Vaccine • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…