The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease.

@article{Levitz1990TheOE,
  title={The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease.},
  author={Ruth Levitz and Dana Chapman and Michal Amitsur and Rachel Green and Larry Snyder and Gabriel Kaufmann},
  journal={The EMBO journal},
  year={1990},
  volume={9 5},
  pages={1383-9}
}
The optional Escherichia coli prr locus restricts phage T4 mutants lacking polynucleotide kinase or RNA ligase. Underlying this restriction is the specific manifestation of the T4-induced anticodon nuclease, an enzyme which triggers the cleavage-ligation of the host tRNALys. We report here the molecular cloning, nucleotide sequence and mutational analysis of prr-associated DNA. The results indicate that prr encodes a latent form of anticodon nuclease consisting of a core enzyme and cognate… CONTINUE READING