The optimum pH of renal adenosine triphosphatase and its variation with the type of ATP.

@article{Michell1977TheOP,
  title={The optimum pH of renal adenosine triphosphatase and its variation with the type of ATP.},
  author={Alastair Robert Michell and Marshall D. Lindheimer and Adrian I. Katz},
  journal={Enzyme},
  year={1977},
  volume={22 5},
  pages={341-7}
}
The in vitro optimum pH of renal (Na+, K+)-ATPase, assumed to be 7.8, depends on the type of ATP used. The accepted value is obtained with 'grade II' ATP but with purer ATP ('Sigma grade') it lies close to the intracellular pH in rat medulla and cortex (pH 7.0, 7.2). Values were identical in rats subjected to dietary potassium depletion for 2-4 weeks. The… CONTINUE READING