The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans

@inproceedings{Levecke2018TheOT,
  title={The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans},
  author={Bruno 4 Levecke and Alice V. Easton and P. J. C. H. Cools and Marco Albonico and Shaali Makame Ame and John S. Gilleard and Jennifer Keiser and Antonio Montresor and Roger K. Prichard and Johnny Vlaminck and Jozef Vercruysse},
  booktitle={International journal for parasitology. Drugs and drug resistance},
  year={2018}
}
The egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack empirical data that allows recommending the optimal time point for a follow-up egg counting. In the present study, we re-analyzed both the kinetics of worm expulsion and egg output for… CONTINUE READING