The optimal number of major histocompatibility complex molecules in an individual.

@article{Nowak1992TheON,
  title={The optimal number of major histocompatibility complex molecules in an individual.},
  author={Martin A. Nowak and K. Tarczy-Hornoch and Jonathan M. Austyn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 22},
  pages={10896-9}
}
A straightforward argument is presented to calculate the number of different major histocompatibility complex (MHC) molecules in an individual that maximizes the probability of mounting immune responses against a large number of foreign peptides. It is assumed that increasing the number of MHC molecules per individual, n, has three different effects: (i) it increases the number of foreign peptides that can be presented; (ii) it increases the number of different T-cell receptors (TCRs… CONTINUE READING