The optimal dose of prophylactic intravenous naloxone in ameliorating opioid-induced side effects in children receiving intravenous patient-controlled analgesia morphine for moderate to severe pain: a dose finding study.

@article{Monitto2011TheOD,
  title={The optimal dose of prophylactic intravenous naloxone in ameliorating opioid-induced side effects in children receiving intravenous patient-controlled analgesia morphine for moderate to severe pain: a dose finding study.},
  author={Constance L. Monitto and Sabine Kost-Byerly and Elizabeth D. White and Carlton K. K. Lee and Michelle A. Rudek and Carol Thompson and Myron Yaster},
  journal={Anesthesia and analgesia},
  year={2011},
  volume={113 4},
  pages={
          834-42
        }
}
BACKGROUND Opioid-induced side effects, such as pruritus, nausea, and vomiting are common and may be more debilitating than pain itself. A continuous low-dose naloxone infusion (0.25 μg/kg/h) ameliorates some of these side effects in many but not all patients without adversely affecting analgesia. We sought to determine the optimal dose of naloxone required to minimize opioid-induced side effects and to measure plasma morphine and naloxone levels in a dose escalation study. METHODS Fifty-nine… CONTINUE READING
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