The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells.

@article{Akakura2004TheOM,
  title={The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells.},
  author={Shin Akakura and Sukhwinder Singh and Matthew Spataro and Reiko Akakura and Jong-Il Kim and Matthew L Albert and Raymond B Birge},
  journal={Experimental cell research},
  year={2004},
  volume={292 2},
  pages={403-16}
}
Opsonization of apoptotic cells facilitates recognition by phagocytes for the rapid clearance of potentially inflammatory cellular material. The secreted glycoprotein Milk Fat Globule Factor-E8 (MFG-E8) is a member of this family of bridging molecules and is believed to bind phosphatidylserine (PS) on the dying cell, linking it to integrin receptors on the phagocyte. Here we report the characterization of a functional signaling module involving MFG-E8, alphavbeta5 integrin, and DOCK180 for the… CONTINUE READING

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