The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia

@article{Benedetti1996TheOE,
  title={The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia},
  author={Fabrizio Benedetti},
  journal={Pain},
  year={1996},
  volume={64},
  pages={535-543}
}
  • F. Benedetti
  • Published 1 March 1996
  • Biology, Psychology, Medicine
  • Pain

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Evidence is reported that placebo analgesia can occur after blockade of opioid mechanisms by naloxone and that n aloxone can produce hyperalgesia independent of the placebo effect.
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This study provides indirect evidence for a cholecystokinin-opiate interaction in humans by examining the effects of morphine and proglumide on human pain visual analogue scale responses to 45–51°C skin temperature stimuli and potentiating proglumide's possible opiate analgesic potentiating effects.
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A significant dose-related effect of naloxone on tension-anxiety was found, suggesting that the endorphins, like exogenously administered opiates, may have antianxiety properties.
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