The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin.

@article{Lee2015TheOM,
  title={The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin.},
  author={Chung-Te Lee and I-Tung Chen and Yi-Ting Yang and T P Ko and Yun-Tzu Huang and Jiun-Yan Huang and Ming-Fen Huang and Shin-Jen Lin and Chien-Yu Chen and Shih-Shun Lin and Donald V. Lightner and Han-Ching Wang and Andrew H-J Wang and Hao-Ching Wang and Lien-I Hor and C. Z. Lo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 34},
  pages={10798-803}
}
Acute hepatopancreatic necrosis disease (AHPND) is a severe, newly emergent penaeid shrimp disease caused by Vibrio parahaemolyticus that has already led to tremendous losses in the cultured shrimp industry. Until now, its disease-causing mechanism has remained unclear. Here we show that an AHPND-causing strain of V. parahaemolyticus contains a 70-kbp plasmid (pVA1) with a postsegregational killing system, and that the ability to cause disease is abolished by the natural absence or experimental… CONTINUE READING
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