The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: preclinical studies in ethanol-preferring and outbred Wistar rats.

@article{June1998TheOR,
  title={The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: preclinical studies in ethanol-preferring and outbred Wistar rats.},
  author={H. June and C. Grey and C. Warren-Reese and L. Durr and A. Ricks-Cord and A. Johnson and S. McCane and L. Williams and D. Mason and R. Cummings and A. Lawrence},
  journal={Alcoholism, clinical and experimental research},
  year={1998},
  volume={22 9},
  pages={
          2174-85
        }
}
Nalmefene, the 6-methylene derivative of naltrexone, was examined after subcutaneous (s.c.) (0.0001 to 8.0 mg/kg) and oral (10 to 80.0 mg/kg) administration in ethanol (EtOH)-preferring rats whose responding (i.e., lever pressing) was maintained by the presentation of EtOH. Naltrexone (0.01 to 40 mg/kg) was used as a reference opioid antagonist. EtOH (10% v/v) and saccharin (0.025 to 0.1% w/v) solutions were concurrently available for 1 hr each day under a two-lever, fixed-ratio schedule in… Expand
Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration.
Central Opioid Receptors Differentially Regulate the Nalmefene-Induced Suppression of Ethanol- and Saccharin-Reinforced Behaviors in Alcohol-Preferring (P) Rats
Pharmacological Evidence for a Motivational Role of κ-Opioid Systems in Ethanol Dependence
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