The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.

@article{Schiller1999TheOM,
  title={The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.},
  author={Peter W. Schiller and Marian E. Fundytus and L Merovitz and Grazyna Weltrowska and Thi M.-D. Nguyen and Carole Lemieux and Nga N. Chung and Terence J. Coderre},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 18},
  pages={3520-6}
}
Opioid compounds with mixed mu agonist/delta antagonist properties are expected to be analgesics with low propensity to produce tolerance and dependence. In an effort to strengthen the mu agonist component of the mixed mu agonist/delta antagonist H-Tyr-Tic-Phe-Phe-NH(2) (TIPP-NH(2)), analogues containing structurally modified tyrosine residues in place of Tyr(1) were synthesized. Among the prepared compounds, H-Dmt-Tic-Phe-Phe-NH(2) (DIPP-NH(2); Dmt = 2',6'-dimethyltyrosine) and H-Dmt-TicPsi[CH… CONTINUE READING

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