The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs.

  title={The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs.},
  author={Hazra S. Moeniralam and Erik Endert and Mari{\"e}tte T Ackermans and J Jan B van Lanschot and Hans P. Sauerwein and Johannes A Romijn},
  journal={The American journal of physiology},
  volume={275 3},
Sufentanil is a synthetic mu-opioid receptor agonist frequently used in anesthesia and critically ill patients. To evaluate the effects of sufentanil on the inflammatory, neuroendocrine, and metabolic responses to endotoxin, we studied six dogs during saline infusion (control), during sufentanil infusion (1.5 microg . kg-1 . h-1), after endotoxin injection (1.0 microg/kg iv), and during combined endotoxin and sufentanil administration. The rate of appearance of glucose was determined by… Expand
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