The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs.

@article{Moeniralam1998TheOS,
  title={The opiate sufentanil alters the inflammatory, endocrine, and metabolic responses to endotoxin in dogs.},
  author={Hazra S. Moeniralam and Erik Endert and Mari{\"e}tte T Ackermans and J Jan B van Lanschot and Hans P. Sauerwein and Johannes A Romijn},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1998},
  volume={275 3},
  pages={E440-E447}
}
Sufentanil is a synthetic μ-opioid receptor agonist frequently used in anesthesia and critically ill patients. To evaluate the effects of sufentanil on the inflammatory, neuroendocrine, and metabolic responses to endotoxin, we studied six dogs during saline infusion (control), during sufentanil infusion (1.5 μg ⋅ kg-1 ⋅ h-1), after endotoxin injection (1.0 μg/kg iv), and during combined endotoxin and sufentanil administration. The rate of appearance of glucose was determined by infusion of [6,6… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Central opiate modulation of peripheral IL‐6 in rats
TLDR
The data show that central opiates are effective modulators of the inflammatory cytokine IL-6, and naloxone methiodide, which does not cross the blood-brain barrier, is not seen. Expand
Plasma profiles of IL-6 and TNF with fever-inducing doses of lipopolysaccharide in dogs.
TLDR
It is concluded that if these cytokines are circulating mediators of fever, they may induce fever in an all-or-none fashion. Expand
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.
TLDR
Epinephrine, either endogenously produced or administered as a component of sepsis treatment, may have a net antiinflammatory effect on the cytokine network early in the course of systemic infection. Expand
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans.
TLDR
The in vivo alterations in organ-specific substrate processing and endogenous mediator production induced by endotoxin were investigated in healthy volunteers and the net cachectin efflux from the splanchnic organs demonstrates that these tissues are a major site for production of this cytokine. Expand
Beta-endorphin inhibits glucose production in the conscious dog.
TLDR
The results suggest that endorphins act on glucose homeostasis in a complex way, both by affecting other glucoregulatory hormones as demonstrated elsewhere, and by directly modulating hepatic glucose production as shown here. Expand
The decrease in nonsplenic interleukin-6 (IL-6) production after splenectomy indicates the existence of a positive feedback loop of IL-6 production during endotoxemia in dogs
TLDR
The spleen is an important mediator in the complete activation of nonsplenic IL-6 production by endotoxin as well as the distribution volume and clearance rate of endotoxin after splenectomy, which results in decreased endotoxin-induced IL- 6 production. Expand
Fentanyl and the beta-endorphin, ACTH and glucoregulatory hormonal response to surgery.
TLDR
Investigation of the effect of the supplementation of nitrous oxide-oxygen anaesthesia with either fentanyl 15 micrograms kg-1 or 0.5% halothane on the beta-endorphin, ACTH, glucoregulatory hormonal and metabolic response to pelvic surgery found it to reflect alterations in pituitary secretion. Expand
Metabolic actions of morphine in conscious chronically instrumented pigs.
TLDR
Effects of a modest dose of morphine sulfate on total body energy metabolism, body thermal status, and the plasma concentrations of certain electrolytes and metabolites were investigated in conscious chronically instrumented pigs, finding increased muscle activity appeared to be the major factor underlying the rise in energy metabolism. Expand
Fentanyl and the metabolic response to gastric surgery
TLDR
It is concluded that the transient metabolic and endocrine benefits produced by fentanyl do not compensate for the severe respiratory problems postoperatively and thus ‘high‐dose fentanyl’ cannot be recommended for upper abdominal surgery. Expand
Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver.
TLDR
The hypothesis that epinephrine can promote IL-6 secretion from IPRL can be supported, with data supporting the hypothesis that the synthesis (or release) of these cytokines was dependent on protein synthesis. Expand
...
1
2
3
...