The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory

  title={The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory},
  author={Michael R Hunsaker and Raymond P. Kesner},
  journal={Neuroscience \& Biobehavioral Reviews},
  • M. Hunsaker, R. Kesner
  • Published 31 January 2013
  • Psychology, Biology
  • Neuroscience & Biobehavioral Reviews
Pattern separation and pattern completion: Behaviorally separable processes?
Although overall accuracies for the two tasks correlated as expected, specific measures of individual variation in holistic retrieval and mnemonic discrimination did not correlate, suggesting that these two processes involve distinguishable properties of episodic memory.
An event-related potential investigation of pattern separation and pattern completion processes
ERP analysis is used to examine neuronal activity during performance of a mnemonic discrimination task and hypothesized that pattern separation processes would be reflected in correct rejection of similar lures while pattern completion processes would are reflected in falsely categorizing lures as repeated.
Tests of pattern separation and pattern completion in humans—A systematic review
Evidence is found that some of the parameters for task validity have been followed in some human studies of pattern separation and pattern completion, but no study was judged to have adequately met all the parametersFor task validity.
Cortical pattern separation and item-specific memory encoding
Pattern separation in the hippocampus through the eyes of computational modeling
A unifying framework is proposed whereby different network, cellular and sub‐cellular mechanisms converge to a common goal: controlling sparsity, the key determinant of pattern separation in the DG.
Pattern Separation: A Key Processing Deficit Associated with Aging?
This chapter reviews studies that have examined age-related changes in pattern separation in humans and rodents and discusses the potential basic science, translational, and clinical implications from these studies to illustrate the need to further examine the relationship between the brain changes associated with aging and pattern separation.
Memory Image Completion (MIC): Establishing a task to behaviorally assess pattern completion in humans
Evidence is presented that the MIC is a reliable behavioral task that targets pattern completion, that is easily and repeatedly applicable, and that is made freely available online.
Memory‐related eye movements challenge behavioral measures of pattern completion and pattern separation
Compared eye movements during the initial presentation of items to eye movements made during the later presentation of item repetitions and similar lures are compared in order to assess mnemonic processing at encoding and retrieval, respectively, suggesting that measures of pattern separation and completion in behavioral paradigms are not process‐pure.
A neural signature of pattern separation in the monkey hippocampus
It is found that, when animals discriminate recently seen novel images from similar (lure) images, behavior indicative of pattern separation, CA3/DG neurons respond to lure images more like novel than repeat images, which will contribute to the understanding of how the brain recognizes differences in the service of making memories.


Less efficient pattern separation may contribute to age-related spatial memory deficits
The present paper will review recently published studies in humans, non-human primates, and rodents that have examined age-related changes in spatial pattern separation to illustrate the need for future research to further examine the relationship betweenatial pattern separation and brain changes associated with aging and neurodegenerative disease.
Pattern separation in the hippocampus
Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off
This analysis is focused on the feedforward pathways from the entorhinal cortex to the dentate gyrus (DG) and region CA3 and finds that Hebbian synaptic modification facilitates completion but reduces separation, unless the strengths of synapses from inactive presynaptic units to active postsynaptic units are reduced (LTD).
A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
Whether specific subregions (dentate gyrus, CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate- term memory is determined.
Pattern separation in the dentate gyrus: A role for the CA3 backprojection
A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.
Further evidence in support of the neurobiological bases of an attribute model of memory: role of the hippocampus.
It can be concluded that there is good support for hippocampal involvement in a working or data-based memory system, but not a reference or expectancy- based memory system.
The organization of memory. A parallel distributed processing perspective.
It is argued that the discovery of semantic structure requires gradual learning, with repeated exposure to representative samples of the structure to be learned, and two neuropsychological implications of the PDP approach are described.
Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map.
CA3 cell ensembles may support the fast acquisition of detailed memories by providing a locally continuous, but globally orthogonal representation, which can rapidly provide a new neuronal index when information is encountered for the first time.
Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
A behavioral impairment in pattern separation was found in a sample of healthy older adults compared with young controls and a specific functional deficit in the CA3/dentate network contributes to memory difficulties with aging, which is consistent with recent fMRI and behavioral reports in healthy aging.