The ontogeny and fate of NK cells marked by permanent DNA rearrangements.

@article{Pilbeam2008TheOA,
  title={The ontogeny and fate of NK cells marked by permanent DNA rearrangements.},
  author={Kristy Pilbeam and Per Basse and Laurent Brossay and Nikola L. Vujanovic and Rachel M. Gerstein and A N Vallejo and Lisa Ann Borghesi},
  journal={Journal of immunology},
  year={2008},
  volume={180 3},
  pages={1432-41}
}
A subset of NK cells bears incomplete V(D)J rearrangements, but neither the consequence to cell activities nor the precise developmental stages in which recombination occurs is known. These are important issues, as recombination errors cause cancers of the B and T lineages. Using transgenic recombination reporter mice to examine NK cell dynamics in vivo, we show that recombination(+) NK cells have distinct developmental patterns in the BM, including reduced homeostatic proliferation and… CONTINUE READING

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