The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

Abstract

p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal stem cells (MSCs) robustly underwent p53LOH, p53LOH in induced embryonic pluripotent… (More)
DOI: 10.1038/cdd.2014.57

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Cite this paper

@article{Shetzer2014TheOO, title={The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele}, author={Yoav Shetzer and Sivan Kagan and Gabriela Koifman and Rachel Sarig and Ira Kogan-Sakin and Meital Charni and Tom Kaufman and Marc Zapatka and Alina Molchadsky and Noa Rivlin and N Dinowitz and S. Levin and Gilad Landan and Ido Goldstein and Naomi Goldfinger and Dana Pe'er and Bernhard Radlwimmer and Peter Lichter and Varda Rotter and Ronit Aloni-Grinstein}, journal={Cell Death and Differentiation}, year={2014}, volume={21}, pages={1419-1431} }