The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells.

@article{Liu2013TheOH,
  title={The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells.},
  author={Qian Liu and Xiao Chun Bai and Hang Li and Yingyi Zhang and Yu Zhao and Xiaodong Zhang and Lihong Ye},
  journal={International journal of cancer},
  year={2013},
  volume={133 6},
  pages={1310-22}
}
Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein and plays a key role in the development of breast cancer. However, its mechanisms of action are poorly understood. Lin28B functions as an oncogene in a variety of human cancers. In our study, we report that HBXIP acts with its partner Lin28B to contribute to carcinogenesis. Our data showed that the expression levels of HBXIP were significantly positively correlated with those of Lin28B in clinical breast cancer tissues. Then, we… CONTINUE READING
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