The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

@article{Bachmann2006TheOS,
  title={The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.},
  author={Malte Bachmann and Christian Kosan and Pei Xiang Xing and Mathias Montenarh and Ingrid Hoffmann and Tarik Moeroey},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 3},
  pages={430-43}
}
The proto-oncogene Pim-1 encodes a serine-threonine kinase which is a downstream effector of cytokine signaling and can enhance cell cycle progression by altering the activity of several cell cycle regulators among them the G1 specific inhibitor p21(Waf), the phosphatase Cdc25A and the kinase C-TAK1. Here, we demonstrate by using biochemical assays that Pim-1 can interact with the phosphatase Cdc25C and is able to directly phosphorylate the N-terminal region of the protein. Cdc25C is… CONTINUE READING
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