The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac.

@article{Nikitakis2009TheOE,
  title={The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac.},
  author={Nikolaos G. Nikitakis and Mark A. Scheper and Vasileios S. Papanikolaou and John J. Sauk},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2009},
  volume={107 6},
  pages={
          826-36
        }
}
OBJECTIVE Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) has been detected in various human cancers and has been linked to tumor development and progression. Oncogenic Stat3 signaling results in induction of specific target genes, among which survivin is implicated in the proliferation and survival of cancer cells. Targeting of Stat3 constitutive expression by the nonsteroidal antiinflammatory drug (NSAID) sulindac has been demonstrated to exert… CONTINUE READING
BETA

Similar Papers